Induction of EndMT results from integration of

2018-10-20

Induction of EndMT results from integration of multiple extrinsic inputs within the dynamically shifting cellular environment of cardiogenesis. Owing to the membrane bound presentation of ligands, Notch signaling status is dependent on the organization and distribution of signal-presenting and signa

Using the combination of a mitogen activated protein

2018-10-20

Using the combination of a mitogen-activated protein kinase kinase (MEK) inhibitor, PD0325901 (PD03), and a glycogen synthase kinase 3 (GSK3) inhibitor, CHIR99021 (CHIR), which will hereafter be referred to as 2i, mouse ESCs (mESCs) are maintained in a ground state (Ying et al., 2008). CHIR activate

Although our model supported viral life cycle there were key

2018-10-20

Although our model supported viral life cycle, there were key elements of the system that required more detailed attention. Despite robust infection, hESC-Heps and primary hepatocytes produce less infectious virions than Huh7 line (Liang et al., 2009; Ploss et al., 2010; Podevin et al., 2010; Roelan

MaSC numbers must be tightly

2018-10-20

MaSC numbers must be tightly regulated through a balance of self-renewal, differentiation, and senescence to prevent tumorigenesis, while accommodating high levels of cell proliferation during pregnancy. Several secreted factors such as WNT and Hedgehog promote self-renewal, but little is known abou

br Experimental Procedures br Acknowledgments br Introductio

2018-10-20

Experimental Procedures Acknowledgments Introduction Embryonic nephron progenitor order Tasquinimod (ENPs) form a population of cells that gives rise to all nephrons in a kidney (Costantini and Kopan, 2010). The balance between maintenance of ENPs and differentiation of the cells to form ne

Another question to address is the potential influence

2018-10-20

Another question to address is the potential influence of the degree of maturity of prepubertal donor tissue on the success of transplantation. Donor age-dependent differential gene expression and subsequent protein expression have been reported in tissue grafts. This could alter the initial ability

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction Induced pluripotent stem 5-ht receptors (iPSCs) have similar properties as embryonic stem cells (ESCs), such as self-renewal and differentiation capacity (Park et al., 2008c; Takahashi and Yamanaka, 2006). Reprogr

br Experimental Procedures br Acknowledgments br Introductio

2018-10-20

Experimental Procedures Acknowledgments Introduction The ability to characterize, isolate, and transplant human muscle stem hydroxycarboxylic acid receptors will lay the foundation for translational efforts to regenerate or engineer human muscles. However, the absence of approaches to expa

br Introduction Hematopoietic stem cells HSCs are a rare sub

2018-10-20

Introduction Hematopoietic stem (-)-JQ1 (HSCs) are a rare subset of cells that possess the abilities of self-renewal and multipotency (Bryder et al., 2006; Gazit et al., 2008). By virtue of these attributes, HSCs can regenerate blood and immune cells throughout life. Prospective isolation of HSC

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2018-07-29