• Pro inflammatory and pro angiogenic factors are known to

  2018-11-05

  

  Pro-inflammatory and pro-angiogenic factors are known to be activated in the diabetic retina. Prominent among these are the inflammatory cytokine, interleukin (IL)-1β, tumor necrosis factor α (TNFα) and IL-6; the adhesion molecules ICAM1 and VCAM1; and the growth factor, vascular endothelial growth

• Deregulation of miRNA expression in cancer subsequently lead

  2018-11-05

  

  Deregulation of miRNA BLZ945 in cancer subsequently leads to altered functionality of these miRNAs. Upregulated miRNAs often act as oncogenes, as exemplified by miR-21 or miR-155 overexpression which causes acute B cell leukemia in transgenic mice models (Medina et al., 2010; Costinean et al., 2006)

• In this study we used a murine model

  2018-11-05

  

  In this study, we used a murine model of Schistosoma japonicum (S. japonicum) to investigate the roles of miR-146a/b, two upregulated miRNAs identified in our previous study (He et al., 2015), in the progression of hepatic schistosomiasis. We found miR-146 was primarily expressed in hepatic macropha

• Potentiation of the HDAC Pin signaling module

  2018-11-05

  

  Potentiation of the HDAC6-Pin1 signaling module by GRK2 in specific breast cancer cells could be envisaged as an adenosine deaminase to enhanced activity of different tumor-promoting cascades that would trigger a self-perpetuating positive feedback cycle promoting cell proliferation and increased s

• During CNTs synthesis the effects of synthesis

  2018-11-05

  

  During CNTs synthesis, the effects of synthesis parameters on the yield of CNTs produced were investigated using a 24 Factorial experimental design which was analyzed in Minitab ANOVA. The summary of the yield results obtained during CNTs synthesis is presented in Table 2. Results as presented indi

• ion channel Interestingly DBS in the medial

  2018-11-05

  

  Interestingly, DBS in the medial or intralaminar thalamus is being used with great success for the treatment of Tourette׳s syndrome [82,83]. One side effect of intralaminar thalamus DBS for Tourette׳s syndrome is profound fatigue. The parameters of stimulation typically include 24h stimulation at hi

• Introduction Duchenne Muscular Dystrophy DMD

  2018-11-05

  

  Introduction Duchenne Muscular Dystrophy (DMD) is an X-linked recessive neuromuscular disease. This fatal disease affects approximately 1:3,500 to 6,000 live male births [1] and 1:50,000,000 live female births [2,3]. It is a neuromuscular disorder characterized by a mutation in the dystrophin (DMD)

• buy EVP-6124 br Material and method br Results and discussio

  2018-11-05

  

  Material and method Results and discussion Conclusion The cantilever arrays are batch fabricated with MEMS technology. An analytical model has been established to eliminate the interference of the adsorption-induced stiffness change and has been applied to precise mass detection of cancer b

• glucocorticoid receptors br Acknowledgements We are grateful

  2018-11-05

  

  Acknowledgements We are grateful to Prof. Kazuyoshi Takagi (Ritsumeikan University) for his useful advice and discussion. This work was supported in part by Japan Science and Technology Agency, CREST, Japan. Introduction Nanomaterials are well known to possess excellent mechanical strength an

• br Materials and methods br

  2018-11-05

  

  Materials and methods Results and discussion Acknowledgments This research was supported in part by NSF through the Partnership for Research and Education in Materials grant (DMR-0611539). Core research facilities were supported by grants from the NSF (CHE-0840450) and NIH (NCRR 8G12MD00758

• A hybrid photonic crystal fiber

  2018-11-05

  

  A hybrid photonic crystal fiber was proposed in [27] which show birefringence of 3.79×10−2 and high nonlinearity of 40.1 W−1km−1 at the wavelength of 1.55μm. In [13], hybrid cladding PCF was proposed where the holes of the cladding wherein different shapes and used for dispersion, a nonlinear effect

• br Conflict of Interest br Author Contributions br Acknowled

  2018-11-03

  

  Conflict of Interest Author Contributions Acknowledgements Introduction Previous studies suggest that impaired glucose regulation may be associated with cancer incidence or cancer-related death. This association was found among patients with diabetes mellitus (Hirakawa et al., 2012; Jee

• br Experimental design materials and

  2018-11-03

  

  2. Experimental design, materials and methods Acknowledgments This work was supported by operating grants from the Canadian Institutes of Health Research (CIHR-27R18706). B.B.F. is the University of British Columbia Peter Wall Distinguished Professor. No competing interests exist for this work

• Yet in spite of the increasing number of

  2018-11-03

  

  Yet, in spite of the increasing number of publications on adults, the neurocognitive mechanisms underlying TO in children are less clear. In a recent study, Johnson and collaborators (Johnson et al., 2015) employed a combined spatio-temporal cueing paradigm and found behavioural evidence that 6–16-y

• Compared to the ERN Ne disparate

  2018-11-03

  

  Compared to the ERN/Ne, disparate findings have been observed regarding Pe amplitude in adult psychopathic offenders. Two previous reports with adult males and females have associated reduced Pe amplitude with increased psychopathy scores (Brazil et al., 2009; Maurer et al., in press). However, a re

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