• br Materials and methods br Results br

  2022-09-30

  

  Materials and methods Results Discussion Our data show that the ghrelin receptor, Ghsr, links energy homeostasis with a form of adult hippocampal plasticity. The presence of Ghsr on mature DG neurons suggest that acyl-ghrelin may modulate NSPCs indirectly, possibly via soluble factors such

• HBTU Studies regarding secretase nowadays aim at elucidating

  2022-09-30

  

  Studies regarding γ-secretase nowadays aim at elucidating how APP is recognized and recruited. It has been suggested based on coarse-grained molecular simulation that the recognition and recruitment of substrate can occur on an extended surface covering PS1's TM2/6/9 domains and PAL motif [15]. Tran

• 5224 First identified in as the second mammalian glutathione

  2022-09-30

  

  First identified in 1982 as the second mammalian glutathione peroxidase [23], we and Stockwell's group demonstrated in 2014 that the selenoperoxidase GPX4 is the key upstream regulator of ferroptosis [12], [13]. The role of GPX4 as the main regulator in the ferroptotic process is based on its unique

• br Site of expression FASTK is expressed

  2022-09-30

  

  Site of expression FASTK is expressed in various parts of human body including heart, skeletal muscle, brain, placenta, lung, liver, kidney pancreas (Ota et al., 2004) and many other organs (Fig. 1). It has been reported that FASTK is highly expressed in pancreatic tumors, where it is involved in

• The neurotransmitter histamine plays a key role in

  2022-09-29

  

  The neurotransmitter histamine plays a key role in the sleep-wake cycle and in learning and memory. Alterations in Doramapimod histamine levels are closely connected with central nervous system dysfunction, and are thought to contribute to neurological disorders, including Alzheimer's disease and d

• br Acknowledgement The work was supported by the

  2022-09-29

  

  6. Acknowledgement The work was supported by the NSFC through Grant Nos. 11535016 and 11475232. It was also supported by CAS. The authors thank their collaborators for beneficial discussions and enthusiastic supports in the simulations and calculations. Introduction Hypoxia-inducible factors

• Significan http www apexbt com

  2022-09-29

  

  Significant DNA damage was observed in hemolymph of molluscs exposed to raw composite tannery effluent as evident from comet assay images. DNA damage was evaluated by the presence of tail resembling that of comet in single strand DNA. Break in DNA strand was reported in the liver and gill Eribulin

• LPC OMe LPC LPC and OMe LPC were shown to

  2022-09-29

  

  LPC 14:0, 2-OMe-LPC 14:0, LPC 16:0 and 2-OMe-LPC 16:0 were shown to be most potent stimulators of intracellular calcium flux in the β cell model, which is one of key processes leading to insulin exocytosis. Yet, species with myristoyl residue initiate calcium influx through voltage-gated LFM-A13 mg

• Growing evidence suggests that the

  2022-09-28

  

  Growing evidence suggests that the glycine site seems to play a pivotal role in NMDAR-related function. For example, it Protease Inhibitor Cocktail (EDTA-Free, 200X in DMSO) has been demonstrated in a hippocampal slice study that the glycine site sub-serves the spatiotemporal detection of synaptic

• Histamine functions as a key neurotransmitter in

  2022-09-28

  

  Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, Phusion high-fidelity DNA polymerase is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the h

• br Acknowledgements br Introduction Protein translation dema

  2022-09-28

  

  Acknowledgements Introduction Protein translation demands high fidelity. There are number of molecular checkpoints to fulfill this demand. Among these, insuring that a particular tRNA gets aminoacylated by its conjugate amino acid, which in turn is catalyzed by a particular aminoacyl-tRNA synt

• The genes for the receptors for peptides

  2022-09-28

  

  The genes for the receptors for peptides similar to glucagon are dispersed on three human chromosomes, with two on chromosome 17 (GCGR and GLP2R) and one each on chromosomes 6 (GLP1R) and 19 (GIPR) (see Table S1). The exon–intron gene structures of these genes are similar, as are the genes for other

• Since the late s synthetic GC e

  2022-09-28

  

  Since the late 1940s, synthetic GC (e.g. prednisone, prednisolone, dexamethasone) have been used extensively in the treatment of chronic inflammatory conditions such as rheumatoid arthritis and asthma, and for their immunosuppressant action in preventing organ rejection post transplantation. Cortico

• br Conclusions According to our

  2022-09-26

  

  Conclusions According to our results we may suggest that FAS c.-671AG SB-3CT or G allele and FASLG gene c.-844T allele were not to be a risk factor, whereas FASLG gene c.-844TC genotype may be protective in the studied Turkish population. Because of the limited sample size in this study, further

• br Cellular directionality To obtain

  2022-09-22

  

  Cellular directionality To obtain a comprehensive understanding of cell migration, it is essential to understand how cues from the cell’s external environment are relayed to the GSK256066 cytoskeleton, so the cell can migrate towards the cue; a process herein referred to as cellular directionali

16542 records 406/1103 page Previous Next First page 上5页 406407408409410 下5页 Last page