• The inhibition of HDAC increases the level of histone acetyl

  2021-11-29

  

  The inhibition of HDAC increases the level of histone acetylation and consequently turns the chromatin to be loose and active, allowing multiple transcription factors to access to promoters of diverse genes including tumor suppressor genes []. As compound possessed potent HDAC inhibitory activity a

• In this precancerous condition though cancer develops from t

  2021-11-29

  

  In this precancerous condition, though cancer develops from the epithelium, the subepithelial connective tissue also play crucial biological role in pathogenesis and progression to malignancy. In this context it may be noted that some recent reports addressed the problem of the mechanical interactio

• br Funding This work was partially supported by

  2021-11-29

  

  Funding This work was partially supported by the National Institute on Alcohol Abuse and Alcoholism, award R00AA021264, startup funds from the Department of Immunology, Herbert Wertheim College of Medicine, and the Office of Research and Economic Development at FIU, and pilot funds from Dr. Werth

• Glycogen synthase kinase GSK is currently considered

  2021-11-29

  

  Glycogen synthase kinase 3 (GSK3) is currently considered to be a multifunctional serine/threonine kinase involved in a wide spectrum of cellular processes such as glycogen metabolism, cell proliferation, neuronal function, oncogenesis or embryonic development (for recent reviews see: Rayasam et al.

• Previously we have shown that the natural flavonoid compound

  2021-11-29

  

  Previously, we have shown that the natural flavonoid compounds that possess C-4 ketone group and C-5 hydroxy group, such as baicalein, luteolin, myricetin and quercetin, effectively inhibit human GLO I. Considering our interest in inhibitors of GLO I and based on the rationale mentioned above, stru

• Herein in consider of the high similarity between

  2021-11-26

  

  Herein, in consider of the high similarity between GR HBP site and AR HBP site, we applied rational drug design strategy to develop AR/GR antagonists based on the chemical structures of antiandrogens and crystal structure of GR. The following bioassay identified Z19 as a dual AR/GR antagonist. Z19 i

• In patients with type diabetes glucagon receptor

  2021-11-26

  

  In patients with type 2 diabetes glucagon receptor antagonism led lowered fasting glucose however not postprandial glucose levels [9], which may reflect that glucagon may not be of particular importance for the diabetic hyperglycemia upon a meal. Current glucagon receptor antagonists have however be

• We and others have previously reported that neurons generate

  2021-11-26

  

  We and others have previously reported that neurons generated from iPSCs with genetic forms of AD recapitulate aspects of the disease, including increased Aβ peptide production in trisomy 21 and APP duplication neurons (Moore et al., 2015, Israel et al., 2012) and increased production of longer form

• Galanin mediates its activity by binding to three

  2021-11-26

  

  Galanin mediates its activity by binding to three G-protein coupled receptor subtypes (designated GAL1-GAL3). Since GAL3 mRNA is found mainly in regions of the mesolimbic dopamine system, such as the ventral tegmental area, dorsal raphe nucleus, LC, amygdala, hippocampus, thalamus, hypothalamus, NAc

• Natural product based drug discovery can be enhanced with co

  2021-11-26

  

  Natural-product-based drug discovery can be enhanced with computational methods [205]. Because most of the reported small-molecule natural inhibitors of fMLF-induced functional responses were not evaluated in Fatostatin A binding assays, we used molecular modeling to predict how well these compound

• Through the analysis of various synthetic GPR agonists

  2021-11-26

  

  Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic ARCA motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early period of discovering TAK-875

• It is well known that histamine functions not only as

  2021-11-26

  

  It is well known that histamine functions not only as an inflammation mediator but also as an aminergic neurotransmitter or neuromodulator. Histaminergic neurons [27], [28] and histamine receptor subtypes (H1R [29] and H3R [30]) are widely existed in mammalian central olfactory system. Histamine reg

• Lastly haspin inhibitor was assessed against

  2021-11-26

  

  Lastly, haspin inhibitor was assessed against a panel of 292 kinases at 10μM. At this high concentration, the R-115777 inhibited thirteen kinases, in addition to haspin, ⩾90%., These kinases were CaMK2b, CaMK2d, CDK7-CycH-Mat1, cGK2, CK1d, CLK1, CLK2, DYRK1A, DYRK1B, DYRK3, PASK, PIM1 and PKD3. I

• It appears that different agonists for GPR activate differen

  2021-11-26

  

  It appears that different agonists for GPR55 activate different signalling pathways [25]. GPR55 activation through LPI has been shown to trigger ERK 1/2 phosphorylation 22, 23, 25, 33. Conversely, endogenous cannabinoid compounds AEA and 2-AG have been shown to have no effect on ERK 1/2 signalling 2

• Ubiquitination of GlyRs subunit on plasma

  2021-11-25

  

  Ubiquitination of GlyRs-α1 subunit on plasma membrane has been shown to initiate the receptor equol and subsequent degradation in lysosomes (Buttner et al., 2001). However, the specific E3 ligase responsible for GlyRs-α1 ubiquitination is largely unknown as yet. Also, the functional consequence of

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