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It is particularly notable that CYP
2020-06-10
It is particularly notable that CYP2D6 appears to be the most stable of the major CYP450 821 in its expression over time in vitro and appears to be least affected by culture conditions and sample to sample variability (i.e., CYP2D6 expression is remarkably consistent over time and between individua
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Oxysterols modulate the immune responses and as such could
2020-06-10
Oxysterols modulate the immune responses and as such could be effectors of the tumor environment: 25-OHC impairs IgA production in B-lymphocytes [26] and induces the secretion of the proinflammatory and angiogenic cytokine IL-8 [27], [28]. Of note, oxysterols (in particular 7α,25-OHC) are potent che
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Enterobacteriaceae are gram negative rods that
2020-06-10
Enterobacteriaceae are gram negative rods that include the Escherichia coli and Shigella. There are several DNA ligases posted on the GenBank belong mostly to Enterobacteria phages, such as the T4 bacteriophage [30]. There are several protein markers used to differentiate between T4 phage superfamil
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Resistance to SP is linked to point mutations
2020-06-10
Resistance to SP is linked to point mutations that accumulate at several sites in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) 900 80 of P. falciparum (Roper et al., 2003). These mutations have been identified in codons 16, 51, 59, 108, and 164 in the dhfr gene and codons 4
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Therefore in this study we determined
2020-06-10
Therefore, in this study we determined whether exogenous LTD, a potent agonist of both CysLT and CysLT receptors , , induces Indirubin receptor edema and AQP4 expression in mouse brain; if so, which subtype of the receptors is involved in AQP4 expression in mouse brain and the cultured rat astrocyt
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br CDKs as Direct Coactivators of Proinflammatory Transcript
2020-06-10
CDKs as Direct Coactivators of Proinflammatory Transcription Factors CDKs fuel inflammation by triggering the function of proinflammatory transcription factors such as NF-κB, STAT3, and AP-1. This is achieved at two levels because CDKs can affect gene expression by targeting global transcription
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In general cellular senescence is considered a programmed re
2020-06-09
In general, cellular senescence is considered a programmed response to stress that can be activated by oxidative stress, irradiation or action of substances or drugs. These stressors cause DNA damage and, through the action of specific proteins (p53 and p21), lead to cell senescence (di Fagagna, 200
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Over the past decade targeting DNA repair
2020-06-09
Over the past decade, targeting DNA repair proteins has emerged as an effective tool to enhance chemosensitivity of malignant cells [9]. However, identification and selection of the proper target of DNA repair pathways is critical to increase cytotoxic activity of chemotherapeutic agents in cancer c
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At the same time that the CPA education requirements
2020-06-09
At the same time that the CPA education requirements have been increasing, the composition of the post-secondary student population has experienced a substantial increase in the number and relative proportion of students who delay college or university matriculation. These students tend to exhibit a
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MLN2238 mg As plants can only take up P
2020-06-09
As plants can only take up P in an inorganic orthophosphate form, it was expected that the proportion of orthophosphate P in the OA would be a good indication of the availability of the P in the OA. While the P speciation of the COMP sample could not be determined by deconvolution due to the broadne
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Enolase is an example of a moonlighting
2020-06-09
Enolase is an example of a moonlighting protein that displays multiple biological actions, including plasminogen, laminin, fibronectin, mucin and cytokeratin binding properties. It has also been described as a complement-evasion protein and as a protein capable of inducing neutrophil trap formation.
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br Materials and methods br Results
2020-06-09
Materials and methods Results and discussion Conclusions Codon-optimized MGSK-Lys-C was expressed at a high level in an optimized expression system as inclusion bodies. The Lys-C activity reached its maximum with about 9340 nkat/Lculture under standard (chemical) refolding conditions. The r
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Tipifarnib Human neutrophil elastase HNE is
2020-06-09
Human neutrophil elastase (HNE) is a serine protease central to the pathology in a wide range of diseases including chronic wounds, cystic fibrosis, and acute respiratory distress syndrome (Owen, 2008). Although neutrophil proteases are necessary for completion of wound healing, HNE is secreted in h
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br Materials and methods br Results
2020-06-09
Materials and methods Results Discussion The effect of progestogen treatment showed some tendencies affecting the body length and weight, however these data were not verifiable statistically. This observation could be explained with the relatively short exposure period and/or the relatively
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In the present study we examined whether the
2020-06-09
In the present study we examined whether the gene for estrogen receptor alpha, Esr1, plays a role in the expression of maternal memory in female rats. The approach utilized a newly developed rat Esr1 knockout (KO) rat model (Rumi et al., 2014) to evaluate whether deletion of the Esr1 GDC-0941 affec
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