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Spingosine phosphate receptors which mediate the action of f
2018-10-23
Spingosine-1-phosphate receptors, which mediate the action of fingolimod and the alpha-4 integrin (CD49d), blocked by natalizumab, have broad expression not only on lymphocytes but also in other mononuclear cells (Marta and Giovannoni, 2012; Martin et al., 2016). Lymphocyte depleting agents could sh
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Chattopadhyay and co workers examined differences in
2018-10-23
Chattopadhyay and co-workers examined differences in resting-state functional connectivity (rsFC) between adolescent patients with MDD and matched healthy controls as well as changes in rsFC following cognitive behavioral therapy (CBT) (). This is one of the largest studies of adolescent MDD to date
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Any intravitreally injected substance must prove efficacy an
2018-10-23
Any intravitreally injected substance must prove efficacy and safety. While our study was not designed as a preclinical safety study, we did not find any obvious structural changes after Sema3f treatment in either of the two in vivo models, which is not surprising given that Sema3f is physiologicall
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Statins hydroxy methylglutaryl coenzyme A HMG CoA reductase
2018-10-23
Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, include lovastatin, simvastatin, mevastatin, fluvastatin, pravastatin, atorvastatin, rosuvastatin and cerivastatin. Statins have been widely used for lowering cholesterol, but recent research reveal other roles, such as a
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diprenorphine The following are the supplementary data relat
2018-10-23
The following are the supplementary data related to this article. Funding Sources This work was supported by the National Mega-projects of Science Research for the 12th Five-year Plan of China grant no. 2012ZX10003008-005, the National High Technology Research and Development of China grant no.
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Three key factors were considered for selecting catchment ar
2018-10-23
Three key factors were considered for selecting catchment areas from a topographic map that were suitable for harnessing hydropower. The key factors were K03861 demand, accessibility and river profile. The catchment areas topographies were studied for determining the appropriate elevation for head
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In this polymorphism assessment our strains
2018-10-23
In this polymorphism assessment, our strains were sampled from Dioscorea alata in Guadeloupe, where anthracnose is the main threat [14] and impacted agro-diversity [15]. Comparisons at wider geographical scales might enlighten important population processes: local dispersal [16], up to migration at
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Ted Hughes suele ser descrito como uno de los
2018-10-22
Ted Hughes suele ser descrito como uno de los más grandes poetas ingleses del siglo , pues incluso llegó prostaglandin receptor obtener la distinción de Poeta Laureado en 1984. Nacido en 1930 en Mytholm- royd, Yorkshire, su familia se mudó a Mexborough cuando él tenía siete años para atender una tie
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Rs is a C T
2018-10-22
Rs1524107 is a C/T single-nucleotide variation on human chromosome 7. It is single nucleotide polymorphisms in interleukin-6 (IL-6) gene. IL-6 are secreted by Toll-like receptor 2-expressing cells in response to the presence of Mycobacterium tuberculosis early in infection and are involved in anti-t
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br Just there just then just that I say
2018-10-22
Just there just then just that I say no to columns, beams, doors and windows from a standard catalog. Instead of making a tasteful selection from the building catalog and becoming a elitist connaisseur of high culture, I am in favor of designing and building project specific building components,
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br The stone sail With regards to environmental and
2018-10-22
The “stone sail” With regards to environmental and technological performance, it must be taken into consideration that the components being assembled dry promote the assembly and subsequent disassembly with full recovery of all elements. They, once disassembled, can be recycled or reused for othe
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Comfortable wind velocity ranges in
2018-10-22
Comfortable wind velocity ranges, in function of the activity exercised outdoors, have been defined by the American Society of Civil Engineers (ASCE)—based on 20% probability of exceedance. Table 1 depicts the wind velocity values—that signify both mean wind velocity and gust equivalent mean velocit
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In this work the study of the
2018-10-22
In this work, the study of the spatial distribution of temperatures in two test CMX001 was based on the concept of the experimental typical day, which represents a specific climate condition according to the Dynamic Climate approach. The possibility of adopting this approach in a short time contrib
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However at the time the Giardino Romano served
2018-10-22
However, at the time, the Giardino Romano served as the pivot of the new irregular trapezoidal plan, with its southern side bordering the remains of the Palazzo Caffarelli and its passageway leading to the stables. Such geometric irregularity hides a historical continuity as shown by the stratigraph
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The third approach is conceived to be more epigraphic
2018-10-22
The third approach is conceived to be more epigraphic. The authors using such approach focus on the iconographic content of the monuments and provide detailed information about the foundation of inscriptions, graphics, Quran verses, and texts. It tries to clarify their cultural meanings (Abdullahi a
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